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The laboratory evaluation in such patients reveals a tremendous increase in alkaline phosphatase to 7-10 times above normal. If the serum bile acids were assayed, it would be found that hepatomegaly they are between 10 and 100 times normal. It is this extreme elevation of bile acids which is felt to cause the generalised pruritis. Liver biopsies which have been performed in such patients show simple biliary status without disruption of the hepatocellular architecture. These changes are completely reversible and hepatomegaly return to normal after the pregnancy ends. hepatomegaly Cholestatis of pregnancy has no adverse effect on pregnancy and the cure of the problem is the delivery of the foetus Attempts at using ion exchange resins such as cholestyramine to try to lower the serum bile acids have been uniformly unsuccessful due to the tremendous elevation in these bile acids. Acute Fatty Liver of Pregnancy A more serious liver disease encountered during pregnancy is that of acute fatty liver.
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