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In some patients, this may be accompanied by hepatic inflammation and liver cell death (steatohepatitis). Potential pathophysiological mechanisms include (1) decreased mitochondrial fatty acid beta-oxidation, (2) increased endogenous fatty acid synthesis or enhanced meningitis delivery of fatty acids to the liver, and (3) meningitis deficient incorporation or export of triglycerides as very-low density lipoprotein.Frequency: In the US: Steatosis affects approximately 25% of the general population. Steatohepatitis may be related to alcohol-induced hepatic damage or may be meningitis unrelated to alcohol (ie, NASH). NASH has been detected in 1.2-9% of patients undergoing routine liver biopsy. NAFLD is found in over 80% of patients who are obese. Over 50% of patients undergoing bariatric surgery have NASH. Mortality/Morbidity: Steatosis is a benign condition, and progression is very rare. Steatohepatitis may progress to liver fibrosis and cirrhosis and may result in liver-related morbidity and mortality.
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