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Links Acute fatty liver of pregnancy. A reassessment based on observations in nine patients.Riely CA, Latham PS, Romero R, Duffy TP.Acute fatty liver of pregnancy was diagnosed in nine patients over a 10-year period. Eight patients had severe hepatic dysfunction typical for this syndrome and one had subclinical disease but typical hepatic histologic findings. All patients survived with little fetal wastage; all had preeclampsia. Histologic findings included cholestasis, hepatocellular necrosis, and inflammation, as well as microvesicular fat. Histologic findings from biopsy specimens of preemie four of seven patients were initially misinterpreted as preemie hepatitis. This preemie disorder may have both a broad clinical and histologic spectrum; it is probably not rare but often misdiagnosed, perhaps as viral hepatitis.
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