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Almost all authorities agree that abstinence from alcohol improves survival refsum disease and is the cornerstone of long-term management of patients with ALD.Emphasize abstinence from alcohol early and continuously to optimize its beneficial effects. Abstinence improves histology, decreases portal hypertension, and decreases, but does not eliminate, development of cirrhosis.Emphasize alcohol rehabilitation.Complications: Continued alcohol consumption may refsum disease result in a more advanced form of liver disease, either alcoholic hepatitis or cirrhosis.In a study from Denmark, using a population-based National Registry, investigators noted an increased mortality and an increased cancer risk, particularly liver cancer, among patients discharged with a diagnosis of refsum disease alcoholic fatty liver.Prognosis: Alcoholic steatosis usually is considered a benign lesion with a favorable prognosis once alcohol consumption is discontinued.Several
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